ChemicalBook CAS DataBase List 5-BROMO-2-(METHYLTHIO)PYRIMIDINE

5-BROMO-2-(METHYLTHIO)PYRIMIDINE synthesis

6synthesis methods

Product Name:5-BROMO-2-(METHYLTHIO)PYRIMIDINE
CAS Number:14001-67-3
Molecular formula:C5H5BrN2S
Molecular Weight:205.08

74-93-1 Synthesis

74-93-1
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$454.02/5MG

32779-36-5 Synthesis

32779-36-5
635 suppliers
$5.00/5g

14001-67-3
135 suppliers
$8.00/250mg

Yield:14001-67-3 75%

Reaction Conditions:

in N,N-dimethyl-formamide at 50; for 3 h;

Steps:

24.1 Step 1: Synthesis of 5-bromo-2-(methylthio)pyrimidine

Step 1:
Synthesis of 5-bromo-2-(methylthio)pyrimidine
To a stirred solution of 5-bromo-2-chloropyrimidine (0.3 g, 1.563 mmol) in DMF (10 mL) was added methyl mercaptan (0.1 mL, 1.563 mmol) at room temperature and heat at 50° C. for 3 h.
Completion of reaction was monitored by TLC.
Reaction mixture was quenched by addition of water, extracted with EtOAc.
Organic portions were combined, dried over Na₂SO₄, evaporated under reduced pressure to obtain crude which was purified by column chromatography using silica gel (100-200 mesh); eluent 5% ethyl acetate/hexane to obtain pure product 5-bromo-2-(methylthio)pyrimidine (0.240 g, 75%) as white solid.
MS: 205.1[M⁺+1]

References:

US2017/291910,2017,A1 Location in patent:Paragraph 0496-0498

32779-36-5 Synthesis

32779-36-5
635 suppliers
$5.00/5g