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ChemicalBook CAS DataBase List 5-Bromo-2-methylpyridine
3430-13-5

5-Bromo-2-methylpyridine synthesis

11synthesis methods
5-Bromo-2-methylpyridine can be used as a pharmaceutical intermediate in the production of cardiovascular and cerebrovascular drugs. Its synthesis method is that the mixtrue of diethyl malonate and sodium hydrogen was stirred for 1h, add 5-nitro-2-chloropyridine in toluene and react for 1.5h at 110℃, then stirred for 15h at RT, and purify to obtain 5-nitro-2-methylmethane pyridine, 94%.
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Yield:-

Steps:

B.39
(B-39) Using 6-methylpyridine-3-ol, with reference to J. Org. Chem. 1967,32,1607, 5-bromo-2-methylpyridine was synthesised. NMR(CDCl3) δ: 2.51(3H, s), 7.05(1H, d, J=8.3Hz), 7.68(1H, d, J=2.5, 8.3Hz), 8.55(1H, d, J=2.3Hz).

References:

SHIONOGI & CO., LTD. EP1422218, 2004, A1 Location in patent:Page 162

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