ChemicalBook CAS DataBase List 5-Bromo-2-fluorobenzylamine hydrochloride

5-Bromo-2-fluorobenzylamine hydrochloride synthesis

6synthesis methods

Product Name:5-Bromo-2-fluorobenzylamine hydrochloride
CAS Number:99725-13-0
Molecular formula:C7H6BrFO
Molecular Weight:205.02

93777-26-5 Synthesis

93777-26-5
362 suppliers
$5.00/5g

5-Bromo-2-fluorobenzylamine hydrochloride

99725-13-0
121 suppliers
$7.00/250mg

Yield: 100%

Reaction Conditions:

Stage #1:5-bromo-2-fluorobenzaldehyde with sodium tetrahydroborate;ethanol at 0 - 20; for 15 h;Inert atmosphere;
Stage #2: with water;ammonium chloride in ethanol at 0;

Steps:

4
Preparation Example 4(5-Bromo-2-fluorophenyl)methanolTo a solution of 5-bromo-2-fluorobenzaldehyde (30.0 g, 148 mmol) in EtOH was added sodium borohydride (8.39 g, 222 mmol) at 0 °C. The resulting mixture was stirred with gradual warming to ambient temperature over 15 h, re-cooled to 0 °C, and quenched with aq. saturated NH₄C1 solution. The mixture was extracted with EtOAc. The organic layer was washed with brine, dried over MgS0₄, filtered and evaporated in vacuo to yield the titled compound (30.3 g, quantitative) as a white sold, which was carried on to the next step without further purification.[M-OH^"]+ 187.

References:

GREEN CROSS CORPORATION;LEE, Jinhwa;KIM, Jeongmin;LEE, Suk Ho;LEE, Junwon;SONG, Kwang-Seop;PARK, Eun-Jung;KIM, Min Ju;SEO, Hee Jeong;LEE, Sung-Han;SON, Eun Jung;KIM, Jong Yup;KANG, Suk Youn;KONG, Younggyu WO2011/159067, 2011, A2 Location in patent:Page/Page column 51

67-56-1 Synthesis