5-Bromo-2-fluorobenzaldehyde synthesis
- Product Name:5-Bromo-2-fluorobenzaldehyde
- CAS Number:93777-26-5
- Molecular formula:C7H4BrFO
- Molecular Weight:203.01
446-52-6
436 suppliers
$6.00/25g
93777-26-5
361 suppliers
$5.00/5g
Yield:93777-26-5 88%
Reaction Conditions:
with potassium bromate;sulfuric acid in water at 90;Reagent/catalyst;Temperature;
Steps:
3
Example three: equipped with electric stirring, thermometer, Dropping funnel and condenser tube reactor was added 65% aqueous sulfuric acid 500ml, Potassium bromate 167 g (1 mol), 124.1 g (1 mol) of o-fluorobenzaldehyde was added dropwise thereto, 90 ° C for 2-3 hours, to the system by adding water 1000ml, Extraction with methyl tert-butyl ether, The organic phase was washed with aqueous sodium sulfite, dried over anhydrous sodium sulfate and concentrated by filtration to remove methyl tert-butyl ether to give a brown-red oil. Vacuum distillation collected 63-65 ° C / 3mmHg fraction 178g, Yield 88%, content 97%.
References:
Shanghai Zhiyan Pharmaceutical Technology Co., Ltd.;Wang Dongwei;Ma Jian;Ye Mao;Zhang Jiyong CN105884591, 2016, A Location in patent:Paragraph 0008; 0009; 0010; 0011
107-31-3
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460-00-4
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$6.00/10g
93777-26-5
361 suppliers
$5.00/5g
99725-12-9
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$11.00/1g
93777-26-5
361 suppliers
$5.00/5g
3132-99-8
493 suppliers
$5.00/10g
93777-26-5
361 suppliers
$5.00/5g