ChemicalBook CAS DataBase List 5-Bromo-2-chlorophenol

5-Bromo-2-chlorophenol synthesis

7synthesis methods

Product Name:5-Bromo-2-chlorophenol
CAS Number:183802-98-4
Molecular formula:C6H4BrClO
Molecular Weight:207.45

16817-43-9 Synthesis

16817-43-9
209 suppliers
$5.00/1g

183802-98-4
169 suppliers
$6.00/1g

Yield:183802-98-4 98%

Reaction Conditions:

Stage #1:5-Bromo-2-chloroanisole with boron tribromide in dichloromethane at 0 - 20; for 20.6667 h;
Stage #2: with water in dichloromethane at 0; for 0.5 h;

Steps:

5
Preparation 5: 5 -Bromo-2-chloro-phenol; A solution of 5 -bromo-2-chloroanisole (20 g, 90.3 mmol) in dichloromethane (100 ml) at 0 "C under nitrogen was treated with borontribromide (1M in dichloromethane, 100 mL, 0.1 mol) dropwise over 2.5 hours. After 10 minutes the reaction was allowed to warm to RT and stirred for 18 hours. The reaction mixture was poured into water (200 mL) and ice (200 mL) and stirred for 30 minutes, dichloromethane (100 mL) was added and the organics separated. The aqueous phase was saturated with sodium chloride and re -extracted with dichloromethane (2x 200 mL). The combined organics were dried (MgSO ₄) to furnish a white solid (18.34 g, 98 %).

References:

PFIZER LIMITED WO2007/91152, 2007, A1 Location in patent:Page/Page column 43

FullText