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ChemicalBook CAS DataBase List 2-BROMO-3-CHLOROPHENOL
855836-62-3

2-BROMO-3-CHLOROPHENOL synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 87 percent / hexane; tetrahydrofuran / 36 h / Heating
2.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 64 percent / 1,2-dibromoethane / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C
3.1: 82 percent / NaOH / ethanol / Heating

References:

Sanz, Roberto;Castroviejo, M. Pilar;Fernandez, Yolanda;Fananas, Francisco J. [Journal of Organic Chemistry,2005,vol. 70,# 16,p. 6548 - 6551]

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