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69033-87-0

5-BROMO-2-(4-METHOXYPHENOXY)PYRIMIDINE synthesis

2synthesis methods
-

Yield:69033-87-0 71%

Reaction Conditions:

Stage #1: 5-bromo-1H-pyrimidin-2-onewith (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;caesium carbonate in tetrahydrofuran at 20; for 0.833333 h;Inert atmosphere;
Stage #2: 4-methoxy-phenolwith caesium carbonate in tetrahydrofuran at 20; for 0.75 h;

References:

Kokatla, Hari Prasad;Lakshman, Mahesh K. [Organic Letters,2010,vol. 12,# 20,p. 4478 - 4481] Location in patent:supporting information; experimental part

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