ChemicalBook CAS DataBase List 5,6-DIHYDROXYINDOLE

5,6-DIHYDROXYINDOLE synthesis

7synthesis methods

Product Name:5,6-DIHYDROXYINDOLE
CAS Number:3131-52-0
Molecular formula:C8H7NO2
Molecular Weight:149.15

5,6-Dihydroxyindole is a melanin precursor with broad-spectrum antibacterial, antifungal, antiviral, and antiparasitic activities. It was synthesized through four steps of demethylation, hydroxyl protection, nitration and reductive cyclization of 3,4-dimethoxyphenylacetonitrile as the raw material.

4318-76-7 Synthesis

4318-76-7
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3131-52-0
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Yield:-

Reaction Conditions:

with dihydrogen peroxide in water

Steps:

8 EXAMPLE 8
EXAMPLE 8 Grey locks which are 90% white are dyed with the composition (A₁) containing 5,6-dihydroxyindole under the conditions described above After drying, a lock dyed dark blonde is thereby obtained. A composition (B₈) containing 1% by weight of 2,5-diaminopyridine in water to which an equal weight of 6% hydrogen peroxide solution has been added (pH of the mixture: 7.3) is applied on this lock for 3 minutes. After rinsing and drying, the lock has a stronger iridescent slightly dark-auburn tint.

References:

L'Oreal US5073174, 1991, A