ChemicalBook CAS DataBase List 2,5-Diaminopyridine

2,5-Diaminopyridine synthesis

6synthesis methods

Product Name:2,5-Diaminopyridine
CAS Number:4318-76-7
Molecular formula:C5H7N3
Molecular Weight:109.13

624-28-2 Synthesis

624-28-2
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4318-76-7
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$20.00/250mg

Yield:4318-76-7 55%

Reaction Conditions:

with [Cu₂(2,7-bis(pyridin-2-yl)-l,8-naphthyridine)(OH)(CF₃COO)3];tetrabutylammomium bromide;ammonia;caesium carbonate in ethylene glycol at 140; for 16 h;Sealed tube;chemoselective reaction;

Steps:

2.2 General procedure for amination
General procedure: A mixture of substrate (0.25 mmol), complex 1 (2.5 × 10^{- 3} mmol), Cs₂CO₃ (1 mmol), Conc. NH_3(aq) (0.5 mL) and TBAB (0.25 mmol) in water (0.5 mL) were loaded in a sealed reaction tube. The reaction temperature was increased to 110-140 °C and the reaction mixture was stirred for 8-24 h. After cooling to RT, the reaction mixture was poured into a saturated NaCl solution, extracted with ethyl acetate and dried over anhydrous MgSO₄. After removal of solvents, the residue was re-crystallized or chromatographed on silica gel. All products were characterized by NMR spectroscopy and were consistent with the literature data.

References:

Liao, Bei-Sih;Liu, Shiuh-Tzung [Catalysis Communications,2013,vol. 32,p. 28 - 31]

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4214-76-0 Synthesis