![34035-03-5](/CAS/GIF/34035-03-5.gif)
5-(4-CHLOROPHENYL)-2-FURALDEHYDE synthesis
- Product Name:5-(4-CHLOROPHENYL)-2-FURALDEHYDE
- CAS Number:34035-03-5
- Molecular formula:C11H7ClO2
- Molecular Weight:206.63
![1-Chloro-4-iodobenzene](/CAS/GIF/637-87-6.gif)
637-87-6
294 suppliers
$38.00/10 G
![2-Formylfuran-5-boronic acid](/CAS/GIF/27329-70-0.gif)
27329-70-0
470 suppliers
$6.00/1g
![5-(4-CHLOROPHENYL)-2-FURALDEHYDE](/CAS/GIF/34035-03-5.gif)
34035-03-5
117 suppliers
$45.95/1gm:
Yield: 95%
Reaction Conditions:
with bis-triphenylphosphine-palladium(II) chloride;sodium carbonate in 1,2-dimethoxyethane;ethanol;water at 65; for 1 h;Suzuki Coupling;
Steps:
Method A- Suzuki Reaction
General procedure: 1.00 mmol arylhalide, 1.30 mmol furfural-boronic acid and 0.05 mmolBis(triphenylphosphine)palladium(II) dichloride were treated with 0.30 mLdimethoxyethane, 0.50 mL ethanol and 0.30 mL aqueous 2M sodium carbonate solution.The reaction was heated to 65°C for 1h or until the TLC showed no remaining startingmaterial. The mixture was evaporated and extracted three times with ethyl acetate. Thecombined organic layers were washed with brine, dried over MgSO4, filtered andconcentrated. The crude product was purified by column chromatography usinghexanes/ethyl acetate (9:1).
References:
Krake, Susann H.;Martinez, Pablo David G.;McLaren, Jenna;Ryan, Eileen;Chen, Gong;White, Karen;Charman, Susan A.;Campbell, Simon;Willis, Paul;Dias, Luiz Carlos [European Journal of Medicinal Chemistry,2017,vol. 126,p. 929 - 936] Location in patent:supporting information
![Furfural](/CAS/GIF/98-01-1.gif)
98-01-1
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$19.69/250g
![4-Chloroaniline](/CAS/GIF/106-47-8.gif)
106-47-8
485 suppliers
$5.00/5 g
![5-(4-CHLOROPHENYL)-2-FURALDEHYDE](/CAS/GIF/34035-03-5.gif)
34035-03-5
117 suppliers
$45.95/1gm:
![4-Bromochlorobenzene](/CAS/GIF/106-39-8.gif)
106-39-8
451 suppliers
$14.00/5g
![2-Formylfuran-5-boronic acid](/CAS/GIF/27329-70-0.gif)
27329-70-0
470 suppliers
$6.00/1g
![5-(4-CHLOROPHENYL)-2-FURALDEHYDE](/CAS/GIF/34035-03-5.gif)
34035-03-5
117 suppliers
$45.95/1gm:
![Furfural](/CAS/GIF/98-01-1.gif)
98-01-1
485 suppliers
$19.69/250g
![1-Chloro-4-iodobenzene](/CAS/GIF/637-87-6.gif)
637-87-6
294 suppliers
$38.00/10 G
![5-(4-CHLOROPHENYL)-2-FURALDEHYDE](/CAS/GIF/34035-03-5.gif)
34035-03-5
117 suppliers
$45.95/1gm:
![5-Bromo-2-furaldehyde](/CAS/GIF/1899-24-7.gif)
1899-24-7
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$13.43/500mgs:
![4-Chlorophenylboronic acid](/CAS/GIF/1679-18-1.gif)
1679-18-1
609 suppliers
$10.00/1g
![5-(4-CHLOROPHENYL)-2-FURALDEHYDE](/CAS/GIF/34035-03-5.gif)
34035-03-5
117 suppliers
$45.95/1gm: