ChemicalBook CAS DataBase List (4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

(4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER synthesis

6synthesis methods

Product Name:(4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
CAS Number:494769-34-5
Molecular formula:C9H12N2O3S
Molecular Weight:228.27

494769-44-7 Synthesis

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

494769-44-7
96 suppliers
$10.00/250mg

(4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

494769-34-5
99 suppliers
$50.00/250 mg

Yield: 78%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane for 2 h;Heating / reflux;

Steps:

N.3
Step 3: (4-Formyl-thiazol-2-yl)-carbamic acid tert-butyl ester; (4-Hydroxymethyl-thiazol-2-yl)-carbamic acid tert-butyl ester (1.62 g, 6.95 mmol) was dissolved in 30 ml dichloromethane. Mangan(IV)oxid (3.65 g, 41.7 mmol) was added and the reaction mixture stirred at reflux for 2 hrs. The suspension was filtered through a dicalite speed plus pad and washed with dichloromethane. The solvents were evaporated and the desired compound was obtained as a light yellow solid (1.25 g, 78%), MS: m/e=229.2 (M+H⁺).

References:

Jaeschke, Georg;Kolczewski, Sabine;Porter, Richard Hugh Philip;Schnider, Patrick;Vieira, Eric US2007/78155, 2007, A1 Location in patent:Page/Page column 32

850429-62-8 Synthesis