(1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID synthesis

4synthesis methods

Product Name:(1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
CAS Number:40678-46-4
Molecular formula:C13H14N2O2
Molecular Weight:230.26

75-07-0 Synthesis

75-07-0
422 suppliers
$14.00/5mL

73-22-3 Synthesis

73-22-3
963 suppliers
$5.00/250mg

(1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID

40678-46-4
17 suppliers
$501.25/5MG

Yield:40678-46-4 91%

Reaction Conditions:

with sulfuric acid in water at 20;

Steps:

1-1 Step 1-1. Synthesis of (1S,3S)-1-Methyl-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indole-3-carboxylic acid:

_{Add 0.5mL concentrated H2SO4 and 40% acetaldehyde aqueous solution (3.5mL, 24.5mmol,1.0 eq) then L-tryptophan (5.0 g, 24.5 mmol, 1.0 eq) was added.The mixture was stirred at room temperature overnight, adjusted to pH=6-7 with 1mol/L sodium hydroxide,A white solid precipitated. Filter the white slurry,The filter cake was washed three times with water to obtain a white solid (5.1 g, 91%).}

References:

CN111303148,2020,A Location in patent:Paragraph 0037

75-07-0 Synthesis

75-07-0
422 suppliers
$14.00/5mL

73-22-3 Synthesis

73-22-3
963 suppliers
$5.00/250mg

40678-46-4
17 suppliers
$501.25/5MG