(4-Vinylphenyl)methanol synthesis

11synthesis methods

Product Name:(4-Vinylphenyl)methanol
CAS Number:1074-61-9
Molecular formula:C9H10O
Molecular Weight:134.18

1076-96-6 Synthesis

1076-96-6
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$31.00/250mg

1074-61-9
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$20.00/100mg

Yield:1074-61-9 82%

Reaction Conditions:

Stage #1: methyl 4-vinylbenzoatewith 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane;lithium tert-butoxide in tetrahydrofuran at 100; for 24 h;Inert atmosphere;
Stage #2: with methanol;sodium hydroxide in tetrahydrofuran at 20;Inert atmosphere;

Steps:

10 The preparation of (4-vinylphenyl) methanol, the structural formula is as follows:

Under nitrogen protection, the raw materials methyl 4-vinylbenzoate (1 mmol) and pinacolborane (2.5 mmol) were added, the catalyst LiOtBu (0.05mol) and the solvent tetrahydrofuran (1.0mL) were reacted at 100°C for 24h, subsequently, 2 mol/L NaOH/MeOH solution (ie, 2 mol of sodium hydroxide per liter of methanol) was added, and the mixture was stirred at room temperature overnight, and the product separation yield was 82%.

References:

CN113860990,2021,A Location in patent:Paragraph 0079-0084

1075-49-6 Synthesis