4-(Trifluoromethyl)benzoic acid synthesis
- Product Name:4-(Trifluoromethyl)benzoic acid
- CAS Number:455-24-3
- Molecular formula:C8H5F3O2
- Molecular Weight:190.12
455-19-6
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455-24-3
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$5.00/5g
Yield:455-24-3 99%
Reaction Conditions:
with oxygen;copper(II) acetate monohydrate;cobalt(II) diacetate tetrahydrate in water at 70; under 760.051 Torr; for 1 h;
Steps:
15 Example 15 Preparation of p-trifluoromethylbenzoic acid by oxidation of p-trifluoromethylbenzaldehyde
Under atmospheric pressure oxygen, water (2mL), p-trifluorobenzaldehyde (1mmol), Cu(OAc)2· H2O (0.003mmol, 0.3% mole fraction) and Co(OAc)2· 4H2O (0.003 mmol, 0.3% mole fraction) was added to a 15 mL glass reaction tube, and an oxygen balloon was connected.The reaction tube was placed in an oil bath heated to 70°C in advance and stirred for 1 hour. After the reaction was completed, the temperature was lowered, the crude product solid was separated by centrifugation, and then ultrasonically washed with 3 mL of water, centrifuged and dried to constant weight to obtain the target product. The separation yield was 99 %.
References:
CN111116348,2020,A Location in patent:Paragraph 0040-0041
349-95-1
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455-24-3
374 suppliers
$5.00/5g
6140-17-6
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$6.00/1g
455-24-3
374 suppliers
$5.00/5g
