4-(Trifluoromethoxy)benzoic acid synthesis
- Product Name:4-(Trifluoromethoxy)benzoic acid
- CAS Number:330-12-1
- Molecular formula:C8H5F3O3
- Molecular Weight:206.12
332-25-2
183 suppliers
$7.00/5g
330-12-1
244 suppliers
$15.00/10 g
Yield:330-12-1 98%
Reaction Conditions:
with sulfuric acid;water;acetic acid at 120;
Steps:
7.2
4-(Trifluoromethoxy)benzoic acid: To a solution of 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) in acetic acid (12 mL) was added water (12 mL) and conc. H2SO4 (12 mL). The reaction mixture was heated overnight at 120° C. Water (100 mL) was added to the reaction mixture and the aqueous solution was extracted from EtOAc (3×100 mL). The combined organic solution was dried (Na2SO4) and concentrated in vacuo to afford the title compound (4.8 g, 98%) as a white solid.
References:
KALYPSYS, INC. US2007/270434, 2007, A1 Location in patent:Page/Page column 16-17
124-38-9
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$175.00/23402
407-14-7
393 suppliers
$5.00/1g
330-12-1
244 suppliers
$15.00/10 g
1736-74-9
193 suppliers
$14.00/5g
330-12-1
244 suppliers
$15.00/10 g
124-38-9
129 suppliers
$175.00/23402
169222-42-8
26 suppliers
$222.00/50ml
330-12-1
244 suppliers
$15.00/10 g
50824-05-0
321 suppliers
$10.00/5g
330-12-1
244 suppliers
$15.00/10 g