4-Pyridinemethaneamine synthesis
- Product Name:4-Pyridinemethaneamine
- CAS Number:3731-53-1
- Molecular formula:C6H8N2
- Molecular Weight:108.14
872-85-5
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3731-53-1
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Yield:3731-53-1 94%
Reaction Conditions:
with ammonium hydroxide;hydrogen in acetonitrile at 60; under 3750.38 Torr; for 12 h;
Steps:
10
Add 1 mmol of 4-pyridinecarboxaldehyde, a ruthenium-based catalyst with a molar weight of 16 mol% of 4-pyridinecarboxaldehyde, ammonia water (25wt%) with a molar ratio of 9 to 4-pyridinecarboxaldehyde, and 5 mL of acetonitrile into a 15 mL reaction kettle. The air in the kettle was replaced 5 times, filled with 2.5MPa hydrogen, heated to 60°C, and reacted at this temperature for 12h.After the reaction, according to the method described in Example 1, cooling and sampling analysis,The conversion rate of 4-pyridinecarbaldehyde is 99%,4-PyridinemethanamineGC yield was 98%,The isolated yield was 94%.
References:
CN113717054,2021,A Location in patent:Paragraph 0104; 0106
100-48-1
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3731-53-1
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696-54-8
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3731-53-1
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1539-39-5
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696-54-8
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3731-53-1
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38557-82-3
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3731-53-1
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