ChemicalBook CAS DataBase List 4-Methoxypyridine N-oxide

4-Methoxypyridine N-oxide synthesis

9synthesis methods

Product Name:4-Methoxypyridine N-oxide
CAS Number:1122-96-9
Molecular formula:C6H7NO2
Molecular Weight:125.13

620-08-6 Synthesis

620-08-6
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$5.00/1g

1122-96-9
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$22.00/1g

Yield:1122-96-9 88%

Reaction Conditions:

with dihydrogen peroxide;acetic acid in water for 24 h;Reflux;Inert atmosphere;

Steps:

14 Synthesis of 4-methoxypyridine 1-oxide
Synthesis of 4-methoxypyridine 1-oxide [0320] To a stirred solution of 4-methoxypyridine (5 g, 45.87 mmol) in acetic acid (25 mL) under argon atmosphere was added a 30%> hydrogen peroxide solution (4.2 mL) at RT. The reaction mixture was stirred at reflux for 24 h. After the consumption of the starting materials (monitored by TLC), the volatile components were removed in vacuo to afford 4- methoxypyridine 1-oxide (5 g, 88%>) as a yellow liquid. LC-MS: 125.9 (M+l); (column; Eclipse XDB C-18 (150 4.6 mm, 5.0 μιη); RT 5.02 min. 0.05% Aq TFA: ACN; 1.0 mL/min); TLC: 5% MeOH:CH₂Cl₂ (R 0.1).

References:

FORUM PHARMACEUTICALS INC.;BURNETT, Duane, A.;BURSAVICH, Matthew, Gregory;MCRINER, Andrew, J. WO2015/66697, 2015, A1 Location in patent:Paragraph 0320

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