4-Hydroxypiperidine hydrochloride synthesis
- Product Name:4-Hydroxypiperidine hydrochloride
- CAS Number:5382-17-2
- Molecular formula:C5H12ClNO
- Molecular Weight:137.61
109384-19-2
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$5.00/1g
5382-17-2
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$9.00/1g
Yield:5382-17-2 99%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 2 h;
Steps:
66.1 [0918] Step 1: Preparation of piperidin-4-ol hydrochloride
A mixture of tert-butyl 4-hydroxypiperidine- 1 -carboxylate (5 g, 24.84 mmol, 1.00 equiv) and HC1 (saturated solution in 30 mL of 1 ,4-dioxane) was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum to afford the title compound (3.4 g, 99%) as an off- white solid.
References:
F. HOFFMANN-LA ROCHE AG;GENENTECH, INC.;CHEN, Huifen;CHU, Yanyan;DO, Steven;ESTRADA, Anthony;HU, Baihua;KOLESNIKOV, Aleksandr;LIN, Xingyu;LYSSIKATOS, Joseph P.;SHORE, Daniel;VERMA, Vishal;WANG, Lan;WU, Guosheng;YUEN, Po-wai WO2015/52264, 2015, A1 Location in patent:Paragraph 0918; 0919
5382-16-1
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5382-17-2
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$9.00/1g
626-64-2
523 suppliers
$6.00/5g
5382-17-2
123 suppliers
$9.00/1g