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ChemicalBook CAS DataBase List 4-Hydroxy Duloxetine
662149-13-5

4-Hydroxy Duloxetine synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: SnCl4 / CH2Cl2 / 0 °C
2: m-CPBA
3: NaOH
4: PPTs / 20 °C
5: NaH / dimethylformamide
6: aq. AcOH / 20 °C

References:

Kuo;Gillespie;Kulanthaivel;Lantz;Ma;Nelson;Threlkeld;Wheeler;Yi;Zmijewski [Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,# 13,p. 3481 - 3486]

1000386-62-8 Synthesis
Duloxetine Impurity 4

1000386-62-8
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