ChemicalBook CAS DataBase List 4-Formylphenylboronic acid pinacol cyclic ester

4-Formylphenylboronic acid pinacol cyclic ester synthesis

12synthesis methods

Product Name:4-Formylphenylboronic acid pinacol cyclic ester
CAS Number:128376-64-7
Molecular formula:C13H17BO3
Molecular Weight:232.08

1122-91-4
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$9.00/10g

73183-34-3
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$6.00/5g

4-Formylphenylboronic acid pinacol cyclic ester

128376-64-7
185 suppliers
$5.00/250mg

Yield:128376-64-7 96%

Reaction Conditions:

with palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride;anhydrous potassium acetate in 1,4-dioxane;Reflux;Inert atmosphere;Suzuki Coupling;

Steps:

General procedure B

General procedure: (for the synthesis of compounds 5, 31, 42 and 45) [1,1' -bis (diphenylphosphine) ferrocene] palladium dichloride (200mg, 0.27mmol), and potassium acetate (1.589g, 16.2mmol) was added into 30mL 1,4-dioxane solution of bromobenzene (5.4mmol) and Bis(pinacolato)diboron (1.647g, 6.49mmol). The mixture was heated to reflux overnight under a nitrogen atmosphere. After extraction and concentrated, the residue was purified by column chromatography to afford the product.

References:

Wu, Yizhe;Zhang, Yu;Guo, Yu;Pan, Zhichao;Zhong, Shichun;Jin, Xinxin;Zhuang, Weihao;Chen, Sikang;Gao, Jian;Huang, Wenhai;Dong, Xiaowu;Che, Jinxin [European Journal of Medicinal Chemistry,2021,vol. 223,art. no. 113637]

302348-51-2 Synthesis