ChemicalBook CAS DataBase List 4-Formylphenylboronic acid

4-Formylphenylboronic acid synthesis

11synthesis methods

Product Name:4-Formylphenylboronic acid
CAS Number:87199-17-5
Molecular formula:C7H7BO3
Molecular Weight:149.94

Potassium phenyltrifluoroborate (184 mg, 1.00 mmol) was added to a solution of iron trichloride (185 mg, 1.10 mmol) in 3 mL of 1:1 THF/water. The mixture was stirred at room temperature for 30 min. The reaction mixture was then passed through a short column containing neutral absorption alumina. The alumina was then washed with a mixture of ethyl acetate/hexanes (2:1) to obtain 4-Formylphenylboronic acid (105 mg, 86%). [The boronic acid products can also be isolated by simple extraction techniques.]

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Yield:87199-17-5 88%

Reaction Conditions:

with Triethoxysilane;iron(III) chloride in methanol; for 12 h;Reflux;

Steps:

2 Example 2Synthesis of Compound 2:

In the air, 25 mL of the reaction flask was sequentially added with ferric chloride (0.05 mmol), alkene 1b (0.5 mmol), triethoxySilane (1.5 mmol) and methanol (2.0 mL). After mixing at room temperature, the reaction mixture was reacted under reflux for 12 h. anti-It should be completed and directly chromatographed to give a yield of 88%.

References:

CN109796293,2019,A Location in patent:Paragraph 0039-0041; 0149