4-Fluoroanisole synthesis
- Product Name:4-Fluoroanisole
- CAS Number:459-60-9
- Molecular formula:C7H7FO
- Molecular Weight:126.13
150-76-5
782 suppliers
$5.00/5 g
459-60-9
358 suppliers
$7.00/5g
Yield:459-60-9 88%
Reaction Conditions:
with 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole;cesium fluoride in 1,4-dioxane at 110; for 20 h;Product distribution / selectivity;Sealed vial;
Steps:
3
Example 3.Evaluation of fluorination reaction with other fluorination reagents and general procedure for fluorination reaction.To 4-methoxyphenol (2.5 mg, 0.020 mmol, 1.0 equiv) in toluene (0.20 mL) at 23 °C was added CsF (9.1 mg, 0.060 mmol, 3.0 equiv), and fluorination reagent (0.0240 mmol, 1.20 equiv). The reaction mixture was stirred at 1 10 °C for 20 h in a sealed vial, then cooled to 23 °C. To the reaction mixture was added 3-nitrofluorobenzene (2.00 μ-, 0.0188 mmol). The yield was determined by comparing the integration of the 19F N R (375 MHz, 23 °C) resonance of 3-nitrofluorobenzene (-1 12.0 ppm). Yields are reported in Table 1.
References:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;RITTER, Tobias;TANG, Pingping WO2012/142162, 2012, A2 Location in patent:Page/Page column 22-23
104-94-9
490 suppliers
$9.00/1g
459-60-9
358 suppliers
$7.00/5g
5720-07-0
466 suppliers
$6.00/5g
459-60-9
358 suppliers
$7.00/5g
