4-ETHOXYCARBONYLOXY-3,5-DIMETHOXYBENZOIC ACID synthesis
- Product Name:4-ETHOXYCARBONYLOXY-3,5-DIMETHOXYBENZOIC ACID
- CAS Number:18780-67-1
- Molecular formula:C12H14O7
- Molecular Weight:270.24
530-57-4
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$13.43/1gm:
541-41-3
6 suppliers
$23.00/5g
18780-67-1
33 suppliers
$50.00/10g
Yield:18780-67-1 74.1%
Reaction Conditions:
with sodium hydroxide in lithium hydroxide monohydrate at 0;
Steps:
2.1.2. Synthesis of 4-ethoxycarbonyl-oxy-3,5-dimethoxy-benzoic acid (III)
1 mol/L sodium hydroxide aqueous solution (800 mL) was added to a 1000 ml round bottom flask, and 3,5-dimethoxy-4-hydroxybenzoic acid (0.33 mol) was added in slowly. Then, ethyl chloroformate (0.33 mol) was added dropwise to keep the temperature of the reaction solution at about 0 C. 3 mol/L hydrochloric acid was used to adjust the pH to 4.0for the white solid. The product was recrystallized with acetone toobtain the white crystal with a yield of 74.1%, which was characterized by 1H NMR in Supplementary Fig. 2.
References:
Wang, Jin;Wei, Jie;Zhou, Yaxin;Chen, Guoguang;Ren, Lili [Fitoterapia,2022,vol. 157,art. no. 105108]
118-41-2
559 suppliers
$14.00/5g
18780-67-1
33 suppliers
$50.00/10g