ChemicalBook CAS DataBase List (4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER

(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER synthesis

13synthesis methods

Product Name:(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER
CAS Number:1552-41-6
Molecular formula:C12H16NO3P
Molecular Weight:253.23

874-89-5 Synthesis

874-89-5
175 suppliers
$6.00/250mg

122-52-1
249 suppliers
$9.00/5g

(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER

1552-41-6
76 suppliers
$45.00/50mg

Yield: 80%

Reaction Conditions:

with tetra-(n-butyl)ammonium iodide at 120; for 24 h;Inert atmosphere;

Steps:

4 Example 4 Triethyl phosphite and 4-cyanobenzyl alcohol were used to prepare diethyl 4- (cyano) benzylphosphonate
To a 20 mL tubular reactor was added 4-cyanobenzyl alcohol (66.5 mg, 0.50 mmol)Triethyl phosphite (166.0 mg, 1.0 mmol, 2.0 equiv.) And tetrabutylammonium iodide (3.7 mg, 0.01 mmol, 2 mol%), vacuum nitrogenAnd then heated to 120 ° C for 24 h under solvent-free conditions. TLC monitoring reaction is complete,The product was purified by column chromatography and the yield was 80%.

References:

Wenzhou University;Xu Qing;Ma Xiantao;Su Chenliang;Han Libiao CN106543221, 2017, A Location in patent:Paragraph 0034; 0035; 0036; 0037

874-86-2 Synthesis