ChemicalBook CAS DataBase List 4-(Chloromethyl)tolunitrile

4-(Chloromethyl)tolunitrile synthesis

10synthesis methods

Product Name:4-(Chloromethyl)tolunitrile
CAS Number:874-86-2
Molecular formula:C8H6ClN
Molecular Weight:151.59

1592-20-7 Synthesis

1592-20-7
283 suppliers
$11.00/5g

874-86-2
277 suppliers
$11.00/5g

Yield:874-86-2 96.2%

Reaction Conditions:

with formic acid;5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)‐porphyrin‐iron(III) chloride;sodium nitrite in acetonitrile at 70; for 4.5 h;

Steps:

14 Synthesis of chloromethyl benzonitrile

To the reaction tube were added 0.4 mmol of p-chloromethylstyrene, 2 mmol of sodium nitrite,5 mg of metallic iron (III) porphyrin, 4.5 ml of acetonitrile solvent, heated and stirred at 70 ° C in an air atmosphere,0.5 ml of formic acid was added dropwise within the first 0.5 hours, and after 4 hours of reaction, heating and stirring were stopped, and the mixture was cooled to room temperature,The crude product was obtained by rotary evaporator, and then purified by column chromatography to give the desired product,The column eluant used was a mixed solvent of petroleum ether and ethyl acetate.The p-chloromethylbenzonitrile structure is shown below:The compound was a white solid with a yield of 96.2% and its nuclear magnetic data was as follows

References:

CN107573259,2018,A Location in patent:Paragraph 0133-0137