4-Chlorobutyl methyl ether synthesis
- Product Name:4-Chlorobutyl methyl ether
- CAS Number:17913-18-7
- Molecular formula:C5H11ClO
- Molecular Weight:122.59
111-32-0
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17913-18-7
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$10.00/1g
Yield:17913-18-7 80%
Reaction Conditions:
with pyridine;thionyl chloride at 0; for 1 h;Heating / reflux;
Steps:
1.A Example 1: Preparation of [ 2-(4-METHOXYBUTYL)-2-ADAMANTYL ACRYLATE] A. Synthesis of 4-methoxybutyl magnesium chloride (4-methoxybutyl Grignard reagent)
52 g of 4-methoxy-l-butanol (0.5 mol) and 40 g of pyridine (0.5 mol) were placed into a 1 liter three-necked flask and then cooled to 0C. Thionyl chloride (119 g, 1.0 mol) was added slowly thereto using a dropping funnel. The mixture was refluxed for about 1 hour, after poured into water to destroy completion of the reaction, excess thionyl chloride extracted with 300 ml of methylene chloride. Then, the organic layer was washed with 5% sodium hydroxide and dried over magnesium sulfate to obtain 4-methoxybutyl chloride (yield: 80%).
References:
ENF TECHNOLOGY CO., LTD. WO2003/104182, 2003, A1 Location in patent:Page 5
109-99-9
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67-56-1
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17913-18-7
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$10.00/1g
124-41-4
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110-56-5
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17913-18-7
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6940-78-9
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124-41-4
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$12.00/25g
17913-18-7
146 suppliers
$10.00/1g