ChemicalBook CAS DataBase List 4-CHLORO-2-METHYLQUINOLINE

4-CHLORO-2-METHYLQUINOLINE synthesis

12synthesis methods

Product Name:4-CHLORO-2-METHYLQUINOLINE
CAS Number:4295-06-1
Molecular formula:C10H8ClN
Molecular Weight:177.63

607-67-0
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$10.00/1g

4295-06-1
139 suppliers
$15.00/1g

Yield:4295-06-1 93%

Reaction Conditions:

with trichlorophosphate at 80; for 5 h;

Steps:

1.1
_{4-chloro-2-methylquinoline (compound d) will be 35mL POCl3A mixture with 5 g of 4-hydroxy-2-methylquinoline was heated to 80 ° C for 5 hours.After cooling to room temperature, the reaction mixture was poured into ice water and neutralized with sodium hydroxide and then extracted with dichloromethane.The combined organic layers were dried over anhydrous sodium sulfate and filtered.Using a concentrated organic layer, a pale yellow purified compound was obtained by using silica gel column chromatography and petroleum ether-ethyl acetate (100:1) as eluent.Yield: 5.18 g (93%).}

References:

Chongqing University of Technology;Li Shuo;You Donghui;Tao Chuanyi;Li Na;Wang Mingqi CN109867625, 2019, A Location in patent:Paragraph 0047; 0049-0050; 0052

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