ChemicalBook CAS DataBase List 4-Bromophenylacetylene

4-Bromophenylacetylene synthesis

11synthesis methods

Product Name:4-Bromophenylacetylene
CAS Number:766-96-1
Molecular formula:C8H5Br
Molecular Weight:181.03

Dimethyl (1-Diazo-2-oxopropyl)phosphonate

90965-06-3
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$30.25/1g

1122-91-4
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$9.00/10g

766-96-1
222 suppliers
$7.00/250mg

Yield:766-96-1 92%

Reaction Conditions:

with potassium carbonate in methanol at 20; for 12 h;

Steps:

General procedure A to obtain ethynyl derivatives:
General procedure: To a solutionof dimethyl 1-diazo-2-oxopropylphosphonate (1.15 g,6.00 mmol) in MeOH (60 mL) were added the corresponding aldehydes(5.00 mmol) and K2CO3 (1.38 g, 10.0 mmol). The reactionmixture was stirred at room temperature for 12 h. After removingthe volatiles without any heating, alkynes 6e9 were purified byflash chromatography using a mixture of petroleum ether andEtOAc 99/1 as eluent.

References:

Ouach, Aziz;Vercouillie, Johnny;Bertrand, Emilie;Rodrigues, Nuno;Pin, Frederic;Serriere, Sophie;Boiaryna, Liliana;Chartier, Agnes;Percina, Nathalie;Tangpong, Pakorn;Gulhan, Zuhal;Mothes, Celine;Deloye, Jean-Bernard;Guilloteau, Denis;Page, Guylene;Suzenet, Franck;Buron, Frederic;Chalon, Sylvie;Routier, Sylvain [European Journal of Medicinal Chemistry,2019,vol. 179,p. 449 - 469]

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