4-(4-BroMophenyl)-2-Methylbut-3-yn-2-ol synthesis

6synthesis methods

Product Name:4-(4-BroMophenyl)-2-Methylbut-3-yn-2-ol
CAS Number:76347-62-1
Molecular formula:C11H11BrO
Molecular Weight:239.11

Benzene, 1-[[[3-(4-bromophenyl)-1,1-dimethyl-2-propyn-1-yl]oxy]methyl]-2-nitro-

1453814-02-2
0 suppliers
inquiry

76347-62-1
16 suppliers
$95.00/1g

Yield:76347-62-1 94%

Reaction Conditions:

in ethyl acetate; for 2 h;UV-irradiation;

Steps:

Light Irradiation of Compounds 1-7

General procedure: 1 (100 mg, 339 μmol) wasdissolved in either CHCl₃, THF, methanol or DCM (15 mL) andstirred for 120 min irradiated by a UV-lamp (365 nm, 200 μWatt/cm²)in a distance of around 2 cm. If the reaction is performed in CDCl₃,the reaction can be followed by NMR (see Scheme 1). The crude product wasextracted with DCM (3 x 30 mL), washed with water (2 x 25 mL), driedover MgSO₄, filtered off and concentrated under reduced pressure.The product was obtained after column chromatography (silica, hexane/ethyl acetate (4:1), R_f=0.33). Compound 8 was obtained (characterization seeabove) (yield: 52 mg, 96%).

References:

Gschneidtner, Tina A.;Moth-Poulsen, Kasper [Tetrahedron Letters,2013,vol. 54,# 40,p. 5426 - 5429] Location in patent:supporting information

589-87-7 Synthesis