ChemicalBook CAS DataBase List 4-Bromobenzocyclobutene

4-Bromobenzocyclobutene synthesis

4synthesis methods

Product Name:4-Bromobenzocyclobutene
CAS Number:1073-39-8
Molecular formula:C8H7Br
Molecular Weight:183.05

694-87-1
145 suppliers
$22.00/250mg

1073-39-8
170 suppliers
$14.00/250mg

Yield:1073-39-8 76.9%

Reaction Conditions:

with bromine in water at 20; for 4.5 h;Cooling with ice;Darkness;Reagent/catalyst;

Steps:

1-2 Preparation of 4-bromobenzocyclobutene

Add 2g (20mmol) of benzocyclobutene to a 50mL three-necked flask, then add 12mL of water solvent, transfer to a stirring table placed in an ice bath and stir (450r/min) in the dark. After starting to stir, use A constant pressure dropping funnel was slowly dropped into 1.2 mL (20 mmol) of liquid bromine, the ice bath was removed after the bromine was dropped, and the reaction was stirred for 4.5 hours in the dark at room temperature. After stopping the reaction, extract the reaction mixture with n-hexane, adjust pH=7, collect the organic phase and remove the organic solvent by rotary evaporation, and then separate the pure monobromo target product (4Br-BCB) obtained by vacuum distillation . The substance is a colorless liquid, the selective yield of monobromine substitution is 76.9%, and the yield of polybrominated substitution is 21.5%.

References:

CN111908998,2020,A Location in patent:Paragraph 0043-0054