ChemicalBook CAS DataBase List 4-(BENZYLOXY)BENZOYL CHLORIDE

4-(BENZYLOXY)BENZOYL CHLORIDE synthesis

12synthesis methods

Product Name:4-(BENZYLOXY)BENZOYL CHLORIDE
CAS Number:1486-50-6
Molecular formula:C14H11ClO2
Molecular Weight:246.69

1486-51-7
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$6.00/1g

1486-50-6
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$45.00/10mg

Yield: 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide at 20; for 2 h;

Steps:

4 Preparation of 4-benzyloxybenzoyl chloride.
Oxalyl chloride (6.5 ml, 75.6 mmol, 1.5 eq.) was added to a suspension of 4-benzyloxybenzoic acid (11.5 g, 50.4 mmol) followed by the addition of DIVIF (0.3 mL, cat.). Gas formation was observed and the mixture was stirred for 2 hours at room temperature during which it became homogeneous. The volatile compounds were removed under reduced pressure (45 °C) and the residue was stripped with toluene, affording a light pink solid (13.4 g, quant.).

References:

ACERTA PHARMA B.V.;BARF, Tjeerd;DE ZWART, Edwin;VERKAIK, Saskia;HOOGENBOOM, Niels;DEMONT, Dennis WO2016/55982, 2016, A1 Location in patent:Paragraph 00171