ChemicalBook CAS DataBase List 4-Acetoxy-2-azetidinone

4-Acetoxy-2-azetidinone synthesis

11synthesis methods

Product Name:4-Acetoxy-2-azetidinone
CAS Number:28562-53-0
Molecular formula:C5H7NO3
Molecular Weight:129.11

930-21-2
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$7.00/100mg

28562-53-0
154 suppliers
$9.00/250mg

Yield: 65%

Reaction Conditions:

with peracetic acid;acetic acid

Steps:

54 Synthesis of 4-acetoxyazetidine-2-one
EXAMPLE 54 Synthesis of 4-acetoxyazetidine-2-one 1.42 g (20 mmol) of azetidine-2-one was added with 1.81 g (22 mmol) of anhydrous sodium acetate, 6.4 g of acetic acid, 5.6 g of ethyl acetate and 0.678 g (2 mmol) of benzene ruthenium dibromide, cooled to 5°-10° C., then added dropwise with 16.5 g of acetic acid solution containing 22% peracetic acid over 1.5 hours while stirring. After the dropping, a further 15 hour stirring was conducted at the same temperature. The solvent was distilled off under reduced pressure, followed by purification by silica gel column chromatography (hexane/ethyl acetate=1/1 by volume) to obtain 1.67 g of 4-acetoxyazetidine-2-one (yield: 65%).

References:

Takasago International Corporation US5204460, 1993, A