ChemicalBook CAS DataBase List 4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine

4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine synthesis

3synthesis methods

Product Name:4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine
CAS Number:89392-03-0
Molecular formula:C13H13N3O4
Molecular Weight:275.26

36315-01-2 Synthesis

36315-01-2
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$18.60/2.5g

1885-14-9 Synthesis

1885-14-9
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$10.00/1g

4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine

89392-03-0
206 suppliers
$6.00/10g

Yield: 83%

Reaction Conditions:

with triethylamine in acetonitrile at 60; for 6 h;Green chemistry;

Steps:

Step-4: Preparation of phenyl 4,6-dimethoxypyrimidin-2-ylcarbamate (6):
To a stirred solution of compound 5 (1 g, 6.45 mmol) in acetonitrile (10 mL) was added triethylamine (0.85 g, 8.40 mmol) followed by phenyl chloroformate (1.31 g, 8.37 mmol) at room temperature. The reaction mixture was heated to 60 °C for 6 h. The reaction mixture was cooled to room temperature and diluted with water (6 mL) and the precipitated solids were filtered and dried under vacuum to obtain compound 6. White solid, Yield: 1.48 g, 83 %; m.p.: 119 °C; ¹H NMR (400 MHz, DMSO-d₆): δ 7.65 (s, 1H), 7.42-7.40 (m, 2H), 7.18-7.14 (m, 3H), 5.80 (s, 1H), 3.96 (s, 6H); ESI-MS: m/z, 276.1 (M+1).

References:

Gilbile, Rohidas;Bhavani, Ram;Vyas, Ritu [Asian Journal of Chemistry,2017,vol. 29,# 7,p. 1477 - 1481]