ETHYL 2-AMINO-4-(2-CHLOROPHENYL)THIOPHENE-3-CARBOXYLATE synthesis
- Product Name:ETHYL 2-AMINO-4-(2-CHLOROPHENYL)THIOPHENE-3-CARBOXYLATE
- CAS Number:325724-66-1
- Molecular formula:C13H12ClNO2S
- Molecular Weight:281.76
2142-68-9
401 suppliers
$6.00/10g
105-56-6
444 suppliers
$10.00/5ml
325724-66-1
26 suppliers
$39.50/1g
Yield:325724-66-1 27%
Reaction Conditions:
Stage #1: 1-(2-chlorophenyl)ethanone;ethyl 2-cyanoacetatewith morpholine in toluene at 120; for 10 h;Gewald Aminoheterocycles Synthesis;
Stage #2: with sulfur in ethanol;toluene at 70; for 10 h;Gewald Aminoheterocycles Synthesis;
References:
Nara, Hiroshi;Kaieda, Akira;Sato, Kenjiro;Naito, Takako;Mototani, Hideyuki;Oki, Hideyuki;Yamamoto, Yoshio;Kuno, Haruhiko;Santou, Takashi;Kanzaki, Naoyuki;Terauchi, Jun;Uchikawa, Osamu;Kori, Masakuni [Journal of Medicinal Chemistry,2017,vol. 60,# 2,p. 608 - 626]
