ChemicalBook CAS DataBase List 2'-Chloroacetophenone

2'-Chloroacetophenone synthesis

13synthesis methods

Product Name:2'-Chloroacetophenone
CAS Number:2142-68-9
Molecular formula:C8H7ClO
Molecular Weight:154.59

5000-66-8 Synthesis

5000-66-8
252 suppliers
$14.00/1g

2142-68-9
394 suppliers
$6.00/10g

Yield:2142-68-9 97%

Reaction Conditions:

with diethyl ether in lithium hydroxide monohydrate at 20; for 1.5 h;Schlenk technique;Irradiation;

Steps:

3. General procedure for the reaction of reductive dehalogenation

General procedure: To a 10 mL schlenk tube, 1 (0.2 mmol), H₂O (1.6 mmol) and Et₂O (4 mL) were added in sequence. The reaction mixture was stirred and irradiated by 40 W Kessil purple LED (390 nm) at room temperature . After the reaction was completed, the reaction mixture was purified by flash column chromatography using PE/EtOAc as the eluent to give the desired product.

References:

Zhang, Jinrong;Chen, Jiajia;Chen, Jianhui;Luo, Yanshu;Xia, Yuanzhi [Tetrahedron Letters,2022,vol. 98,art. no. 153835] Location in patent:supporting information

873-31-4 Synthesis