3-(TRIFLUOROACETYLAMINO)-1-PROPANOL synthesis
- Product Name:3-(TRIFLUOROACETYLAMINO)-1-PROPANOL
- CAS Number:78008-15-8
- Molecular formula:C5H8F3NO2
- Molecular Weight:171.12
383-63-1
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156-87-6
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78008-15-8
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Yield:78008-15-8 100%
Reaction Conditions:
at 0 - 20;
Steps:
4.1.2 General procedure for the synthesis of 23 and 24
General procedure: To a cooled solution (0°C) of the appropriate aminoalcohol (1 eq) was added dropwise ethyltrifluoroacetate (1.2 eq) and the resulting mixture was stirred at room temperature of 2h. The solvent was evaporated in vacuum and the product obtained was used without further purification. 4.1.2.1 2,2,2-Trifluoro-N-(3-hydroxypropyl)acetamide (23) Yellow oil, quantitative yield; 1H NMR (400MHz, CDCl3) δ 1.70-1.78 (m, 2H), 3.18 (t, 2H, J=5.1Hz), 3.69 (brs, 1H, exch D2O), 3.52 (t, 2H, J=4.8Hz), 8.74 (brs, 1H, exch D2O) ; 13C NMR (100MHz, CDCl3) δ 30.5, 38.4, 61.0, 115.9, 157.8 ; HMRS (esi) m/z calcd for C5H9F3NO2 [M+H] 172.0585, found 172.0576.
References:
Milelli, Andrea;Marchetti, Chiara;Greco, Maria Laura;Moraca, Federica;Costa, Giosuè;Turrini, Eleonora;Catanzaro, Elena;Betari, Nibal;Calcabrini, Cinzia;Sissi, Claudia;Alcaro, Stefano;Fimognari, Carmela;Tumiatti, Vincenzo;Minarini, Anna [European Journal of Medicinal Chemistry,2017,vol. 128,p. 107 - 122]
431-47-0
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156-87-6
476 suppliers
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78008-15-8
24 suppliers
$620.24/1ML
156-87-6
476 suppliers
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407-25-0
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78008-15-8
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354-32-5
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156-87-6
476 suppliers
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78008-15-8
24 suppliers
$620.24/1ML
109317-75-1
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156-87-6
476 suppliers
$5.00/10g
78008-15-8
24 suppliers
$620.24/1ML