ChemicalBook CAS DataBase List 3-Thiophenecarbonyl chloride

3-Thiophenecarbonyl chloride synthesis

7synthesis methods

Product Name:3-Thiophenecarbonyl chloride
CAS Number:41507-35-1
Molecular formula:C5H3ClOS
Molecular Weight:146.59

22913-26-4 Synthesis

22913-26-4
137 suppliers
$8.00/1g

41507-35-1
118 suppliers
$45.00/100mg

Yield:-

Reaction Conditions:

with sulfuryl dichloride;sodium hydroxide in tetrahydrofuran;water at 20 - 60;

Steps:

12.1 12.1 Synthesis of 3-thienylcarbonyl chloride
Methyl 3-thienylcarboxylate (1.42 g, 10 mmol) was dissolved in 30 mL THF.An aqueous solution (10 ml) of NaOH (0.8 g, 20 mmol) was added at room temperature.The reaction was stirred at 60 °C.TLC testing,After the reaction was completed, it was cooled to room temperature and made acidic with 2M hydrochloric acid.Extracted with ethyl acetate (3 x 30 ml),After the organic phase is combined,Water separately,Saturated saline solution,Dry over anhydrous sodium sulfate.Rotating to remove the solvent,To obtain a crude product of 3-thienylcarbonyl chloride,Can be used directly in the next step.

References:

Taizhou Pharmaceutical Chengguoke Huawu Bio-pharmaceutical Technology Co., Ltd.;Liang Xinmiao;Zhao Yaopeng;Wang Changjian;Wang Jixia;Zhang Xiuli;Liu Yanfang CN108383775, 2018, A Location in patent:Paragraph 0356; 0358-0361

88-13-1 Synthesis