3-TERT-BUTYL-4-HYDROXYBENZOIC ACID METHYL ESTER synthesis

9synthesis methods

Product Name:3-TERT-BUTYL-4-HYDROXYBENZOIC ACID METHYL ESTER
CAS Number:39778-63-7
Molecular formula:C12H16O3
Molecular Weight:208.25

67-56-1 Synthesis

67-56-1
759 suppliers
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66737-88-0
58 suppliers
$55.00/250mg

3-TERT-BUTYL-4-HYDROXYBENZOIC ACID METHYL ESTER

39778-63-7
20 suppliers
$55.00/100mg

Yield:39778-63-7 97%

Reaction Conditions:

with thionyl chloride for 2 h;Reflux;

Steps:

3.2 Step 2: methyl 3-tert-butyl-4-hydroxybenzoate

3-tert-butyl-4-hydroxybenzoic acid (4.0 g, 21 mmol) was dissolved in 100 ml of methanol,A solution of dichlorosulfoxide (12.0 g, 100 mmol)Heated to reflux for 2h.The reaction solution was cooled to room temperature,Concentrated under reduced pressure to a viscous solid,Add a small amount of methanol diluted,add water,filter,The filter cake is washed with a small amount of water,Dry,To obtain 4.2 g of a white solid,Yield 97%.

References:

CN106432159,2017,A Location in patent:Paragraph 0085; 0086

67-56-1 Synthesis

67-56-1
759 suppliers
$9.00/25ml

201230-82-2 Synthesis