3-Phenyltoluene synthesis
- Product Name:3-Phenyltoluene
- CAS Number:643-93-6
- Molecular formula:C13H12
- Molecular Weight:168.23
Yield:643-93-6 98.3%
Reaction Conditions:
with palladium;sodium carbonate in water;N,N-dimethyl-formamide at 100; for 0.166667 h;Green chemistry;Suzuki Coupling;
Steps:
General Suzuki reaction procedure
General procedure: To a 25 mL two neck round bottom flask attached with a reflux condenser, were added the aryl halide (1 mmol), boronic acid (1.25 mmol), Na2CO3 (2 mmol), and Pd nanoparticles (0.94 mol %) in 4 mL DMF or DMF/H2O (1:1), and the reaction mixture heated at the appropriate temperature and duration. The reaction was monitored by gas chromatography. After the reaction was complete, the mixture was extracted with ethyl acetate three times, the combined organic extracts dried over anhydrous Na2SO4 and the solvent evaporated at reduced pressure. The crude products were then purified by column chromatography [hexane or hexane/ethyl acetate (9:1)] and analyzed by GC, LC-MS, and NMR.
References:
Bendre, Ameya D.;Kodam, Kisan M.;Patil, Viraj P.;Terdale, Santosh S.;Waghmode, Suresh B. [Journal of Organometallic Chemistry,2020,vol. 909] Location in patent:supporting information
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643-93-6
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643-93-6
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