ChemicalBook CAS DataBase List 3-METHYL-THIOBENZAMIDE

3-METHYL-THIOBENZAMIDE synthesis

4synthesis methods

Product Name:3-METHYL-THIOBENZAMIDE
CAS Number:2362-63-2
Molecular formula:C8H9NS
Molecular Weight:151.23

620-22-4 Synthesis

620-22-4
220 suppliers
$11.00/25mL

2362-63-2
80 suppliers
$11.00/1g

Yield: 87%

Reaction Conditions:

with sodiumsulfide nonahydrate in N,N-dimethyl-formamide at 130; for 2.5 h;

Steps:

The general procedure of preparing all thioamides
General procedure: Benzonitrile 1a (1 mmol), Na2S*9H2O (1.2 mmol) and DMF (1 mL) were added into a 10 mL bottle. The reactor was placed in a heating magnetic stirrer at 130 °C. After 2.5 h, by adding about 3 mL H2O after the reaction to disperse the solid product, the reaction mixture was extracted with EtOAc (3 x 3 mL), and the mixture was purified by column chromatography.

References:

Cao, Xian Ting;Yang, Huiyong;Zheng, Hui;Zhang, Pengfei [Heterocycles,2018,vol. 96,# 3,p. 509 - 517]