3-Methyl-quinoxaline-2-carboxylic Acid synthesis
- Product Name:3-Methyl-quinoxaline-2-carboxylic Acid
- CAS Number:74003-63-7
- Molecular formula:C10H8N2O2
- Molecular Weight:188.18
61522-54-1
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74003-63-7
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Yield:74003-63-7 87%
Reaction Conditions:
Stage #1:2-Methylchinoxalin-3-carbonsaeuremethylester with sodium hydroxide;water in methanol for 0.5 h;
Stage #2: with hydrogenchloride in methanol;water
Steps:
5
3-Methyl-quinoxaline-2-carboxylic acid methyl ester (0.20 g, 0.99 mmol) was dissolved in methanol (8 mL) and 2 N sodium hydroxide (2 mL). The mixture was stirred for 30 minutes, then concentrated to about of its volume, acidified with 1 N hydrochloric acid and extracted with ethyl acetate. The combined extracts were washed with water and brine, dried over magnesium sulfate and concentrated to a solid which was dried on high vacuum (0.16 g, 87%).
References:
Pfizer Inc US2005/43292, 2005, A1 Location in patent:Page/Page column 12
25519-55-5
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74003-63-7
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$72.00/5mg
2379-55-7
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74003-63-7
109 suppliers
$72.00/5mg
480-96-6
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74003-63-7
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$72.00/5mg
13297-18-2
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74003-63-7
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