ChemicalBook CAS DataBase List 3-METHYL-1H-INDAZOLE

3-METHYL-1H-INDAZOLE synthesis

11synthesis methods

Product Name:3-METHYL-1H-INDAZOLE
CAS Number:3176-62-3
Molecular formula:C8H8N2
Molecular Weight:132.16

551-93-9 Synthesis

551-93-9
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$6.00/5g

3176-62-3
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$9.00/250mg

Yield:3176-62-3 90%

Reaction Conditions:

Stage #1: 1-(2-aminophenyl)ethan-1-onewith hydrogenchloride;NaNO₂ in lithium hydroxide monohydrate at 0 - 10; for 1 h;
Stage #2: with hydrogenchloride;stannous chloride monohydrate in lithium hydroxide monohydrate;

Steps:

3.3 Synthesis of 3-methyl-1H-indazole

2-aminoacetophenone (81 g) was added to 600 ml of hydrochloric acid (37%), and the aqueous solution of NaNO2 (80 g of sodium nitrite was added to 400 ml of water) was added dropwise at 0 to 10 ° C for 1 hour, and SnCl2 H2O hydrochloric acid solution (200 g dissolved in 300 ml hydrochloric acid (37%)) was stirred overnight. The reaction solution into the ice water filtration, the filtrate adjusted PH = 8,A large amount of solid precipitated and filtered to give 71 g of an off-white solid in 90% yield.

References:

CN102898374,2016,B Location in patent:Paragraph 0049; 0050

445-27-2 Synthesis