ChemicalBook CAS DataBase List 2'-Fluoroacetophenone

2'-Fluoroacetophenone synthesis

13synthesis methods

Product Name:2'-Fluoroacetophenone
CAS Number:445-27-2
Molecular formula:C8H7FO
Molecular Weight:138.14

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445-27-2
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Yield:445-27-2 99 %

Reaction Conditions:

with air;silica gel at 20;Irradiation;

Steps:

2. General procedure for the synthesis of products.

General procedure: A 10 mL tube equipped with a magnetic stirring bar was charged with Ketoxime (0.4 mmol,), Silica gel (60 mg), DCM (1 mL) and HFIP (1 mL). The mixture was irradiated by 10 W blue LEDs, then stirred at room temperature under the open air for hours. After completion of the reaction, the reaction mixture was extracted with water and ethyl acetate (3×4 mL). The combined organic phases were dried over anhydrous Na2SO4, and then concentrated under reduced pressure on a rotary evaporator. The desired amide was obtained after purification of the concentrate by flash chromatography on silica gel with petroleum ether/ethyl acetate (9:1 to 1:1).

References:

Shen, Qing;Peng, Xiaoyan;Chen, Dan;Liu, Yutong;Jiang, Hezhong;Li, Jiahong [Tetrahedron Letters,2023,vol. 114,art. no. 154286] Location in patent:supporting information

766-49-4 Synthesis