3-Methoxybenzenethiol synthesis
- Product Name:3-Methoxybenzenethiol
- CAS Number:15570-12-4
- Molecular formula:C7H8OS
- Molecular Weight:140.2
766-85-8
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15570-12-4
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Yield:15570-12-4 89%
Reaction Conditions:
with sodiumsulfide nonahydrate;copper;ethane-1,2-dithiol in dimethyl sulfoxide at 100; for 20 h;Inert atmosphere;Green chemistry;
Steps:
General Experimental Procedure for the Synthesis of ArylThiols from Aryl Iodides
General procedure: To a test tube containing a magnetic bar was added aryl iodide(1 mmol), copper powder (6.35 mg, 0.1 mmol), Na2S·9H2O(720.54 mg, 3 mmol), and DMSO (2 mL). After flushing withargon, 1,2-ethanedithiol (8.4 μL, 0.1 mmol) was added. Themixture was stirred in the oil bath at 100 °C for 20 h. Aftercooled to ambient temperature, the reaction mixture was distributedin aq HCl (5%) and EtOAc. The organic layer was separated and washed with water and brine, dried, and concentratedunder vacuum. The crude product was further purifiedby column chromatography using ethyl acetate/n-hexane aseluent to provide the desired aryl thiol.
References:
Xue, Hongyu;Jing, Bing;Liu, Shasha;Chae, Junghyun;Liu, Yajun [Synlett,2017,vol. 28,# 17,art. no. ST-2017-W0384-L,p. 2272 - 2276]
2388-74-1
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15570-12-4
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50667-88-4
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15570-12-4
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150-19-6
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15570-12-4
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50667-83-9
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15570-12-4
242 suppliers
$17.00/1g