3-Methoxy-2-methylaniline synthesis
- Product Name:3-Methoxy-2-methylaniline
- CAS Number:19500-02-8
- Molecular formula:C8H11NO
- Molecular Weight:137.18
77-78-1
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19500-02-8
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Yield: 89%
Reaction Conditions:
Stage #1:3-amino-6-iodo-2-methyl-2-cyclohexen-1-one with potassium tert-butylate in tetrahydrofuran at -15 - 5; for 1 h;
Stage #2:dimethyl sulfate in tetrahydrofuran at 5; for 2 h;
Steps:
2.24 g (20 mmol, 2 eq) of potassium tert-butoxide is dissolved in 60 ml of anhydrous THF and the resulting solution is cooled to -15 0C with stirring. A solution of 2.51 g (10 mmol, 1 eq) of 3-amino-6-iodo-2-methyl-2-cyclohexen-l-one in 25 ml anhydrous THF is added to the potassium tert-butoxide solution and the temperature is kept below
References:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG WO2007/130704, 2007, A1 Location in patent:Page/Page column 6-7
4837-88-1
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19500-02-8
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5460-31-1
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19500-02-8
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164082-77-3
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19500-02-8
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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19500-02-8
219 suppliers
$9.00/1g