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ChemicalBook CAS DataBase List 3-Hydroxy-2-methylpyridine
1121-25-1

3-Hydroxy-2-methylpyridine synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: NH2OH*HCl, NaOH / ethanol; H2O / 0.33 h / Heating
2: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature
3: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min

References:

Kuo;Shih [Chemical and Pharmaceutical Bulletin,1991,vol. 39,# 1,p. 181 - 183]

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