
3-Fluoropyridine-4-carboxylic acid synthesis
- Product Name:3-Fluoropyridine-4-carboxylic acid
- CAS Number:393-53-3
- Molecular formula:C6H4FNO2
- Molecular Weight:141.1

124-38-9
130 suppliers
$175.00/23402

393-53-3
198 suppliers
$10.00/1g
Yield:393-53-3 70%
Reaction Conditions:
Stage #1:3-Fluoropyridine with n-butyllithium;diisopropylamine in tetrahydrofuran at -78; for 1 h;
Stage #2:carbon dioxide in tetrahydrofuran at -78 - 20; for 1 h;
Stage #3: with hydrogenchloride in tetrahydrofuran;water; pH=5
Steps:
1
3-Fluoropyridine (25 g, 257mmol) was added to a solution of butyllithium EPO
References:
MITSUBISHI PHARMA CORPORATION;SANOFI-AVENTIS WO2006/36015, 2006, A2 Location in patent:Page/Page column 121-122

372-47-4
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124-38-9
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$175.00/23402

393-53-3
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$10.00/1g

372-47-4
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$5.00/1g

393-53-3
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$10.00/1g

399-88-2
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$6.00/250mg

393-53-3
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$10.00/1g

3430-27-1
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$13.43/1gm:

393-53-3
198 suppliers
$10.00/1g