ChemicalBook CAS DataBase List 3-Chloro-2-methylbenzoic acid

3-Chloro-2-methylbenzoic acid synthesis

11synthesis methods

Product Name:3-Chloro-2-methylbenzoic acid
CAS Number:7499-08-3
Molecular formula:C8H7ClO2
Molecular Weight:170.59

608-23-1
108 suppliers
$25.00/5g

64-19-7 Synthesis

64-19-7
1553 suppliers
$10.00/25ML

7499-08-3
177 suppliers
$8.00/10g

Yield:7499-08-3 60%

Reaction Conditions:

with oxygen at 100 - 105; under 750.075 Torr; for 1 h;Autoclave;Temperature;Pressure;Reagent/catalyst;

Steps:

1
280 g of 3-chloro-o-xylene (2 mol), 28 g of acetic acid and 0.28 g ofcobalt-manganese bromide composite catalystwere added to a 500 ml autoclave(the catalyst included 0.136 g of cobalt acetate tetrahydrate, 0.105 g of manganese acetate tetrahydrate and0.039g ofpotassium bromide) , Stirring, heating to 100 ~ 105 .Slowly through the oxygen so that the pressure inside the kettle to0.1Mpa, oxygen into the way intermittent oxygen, the control of the internal temperature of 100 ~ 105 , about 1h pass.The concentrate wascooledto -0.095Mpa and the solvent was distilled off (the distillate was mainly acetic acid and can be recovered). The concentrate wascooled, filtered and dried to obtain 203.8 g of 2-methyl-3-chlorobenzoic acid, 98.5% purity,60%.

References:

Jiangsu Lianhua Technology Co., Ltd.;Lianhua Science And Technology (Yancheng) Co., Ltd.;Lianhua Science And Technology (Taizhou) Co., Ltd.;Fan Xiaobin;Lin Xingjun;Yang Wei CN106946685, 2017, A Location in patent:Paragraph 0040-0041; 0044; 0047; 0050; 0052

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