ChemicalBook CAS DataBase List 3-Bromodibenzo[b,d]furan

3-Bromodibenzo[b,d]furan synthesis

10synthesis methods

Product Name:3-Bromodibenzo[b,d]furan
CAS Number:26608-06-0
Molecular formula:C12H7BrO
Molecular Weight:247.09

[1,1'-Biphenyl]-2-ol, 4'-bromo-2'-fluoro-

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Yield:26608-06-0 80%

Reaction Conditions:

with potassium carbonate in 1-methyl-pyrrolidin-2-one at 185; for 1.5 h;

Steps:

A-3 (A-3) Synthesis of Intermediate A-3

In argon atmosphere, a solution of Intermediate A-2 synthesized in the step (A-2) (561 g, 2.10 mol) and potassium carbonate (580 g, 4.20 mol) in N-methyl-2-pyrrolidone (NMP) (6 L) was stirred at 185° C. for 1.5 h. The reaction liquid was cooled and stirred after adding water. The generated solid matter was collected by filtration and washed with water. The obtained solid was dissolved into toluene and the insoluble was removed by filtration. The filtrate was concentrated. The crystal obtained by adding heptane was collected by filtration to obtain Intermediate A-3 (414 g). The yield was 80%.

References:

US2020/24263,2020,A1 Location in patent:Paragraph 0305; 0308