ChemicalBook CAS DataBase List 3,5-Dichloro-2,4,6-trifluoropyridine

3,5-Dichloro-2,4,6-trifluoropyridine synthesis

9synthesis methods

Product Name:3,5-Dichloro-2,4,6-trifluoropyridine
CAS Number:1737-93-5
Molecular formula:C5Cl2F3N
Molecular Weight:201.96

2176-62-7 Synthesis

2176-62-7
263 suppliers
$12.00/10g

1737-93-5
264 suppliers
$30.80/5g

Yield:1737-93-5 95.42%

Reaction Conditions:

with potassium fluoride at 90; for 1.5 h;Temperature;Reagent/catalyst;Concentration;

Steps:

12 Example 12: A process for the preparation of 3,5-dichloro-2,4,6-trifluoropyridine,Specific operations are as follows:
In a 1000 mL three-necked flask, add 600 mL of DMI and anhydrous KF146.72 g with a purity of 99% and a particle size of 20-50 um. Stirring and distilling under reduced pressure (130-135 ° C / 60 mmHg)60 g solvent with water evaporation, the measured water content of less than 1000 ppm, heated to 90 ° C, adding purity of 97% of the five chloropyridine 129.40 g, After 1.5 h of incubation, heating was stopped, the reaction mixture was cooled and the reaction mixture was filtered to obtain filtrate and residue. The residue was washed with 100 mL of DMI and suction filtered to obtain a washing solution. Combined washing liquid and filtrate, distillation, collecting 65 ~ 70 , 5 KPa fractions, namely 3,5-dichloro-2,4,6-trifluoropyridine

References:

Sichuan Fusida Biotechnology Development Co., Ltd;Luo, Qian;Peng, Zhou;Li, Zhou;Wang, Lei;Zhang, Hua;Pi, Yawei CN106008331, 2016, A Location in patent:Paragraph 0059; 0063

FullText

2176-62-7 Synthesis

2176-62-7
263 suppliers
$12.00/10g